Ukuphathwa ngokunemba kwe-eosinophilic asthma: indlela yesayensi yokuthuthukisa ikhwalithi yempilo

Ukuphathwa ngokunemba kwe-eosinophilic asthma: indlela yesayensi yokuthuthukisa ikhwalithi yempilo

I-Eosinophilic Asthma (EA) i-subtype ehlukile ye-asthma ebonakala ngokwanda okungajwayelekile kwama-eosinophils emigwaqweni yomoya, okuholela ekuvuvukeni okungamahlalakhona. Ucwaningo luphakamisa ukuthi cishe ama-40% eziguli ze-asthma ezindala angaba ne-EA, ngokwezifundo zemitholampilo. Lesi simo sivame ukuphendula kabi ku-corticosteroid ukwelashwa okujwayelekile futhi kuvame ukuhlotshaniswa ne-comorbidities efana nama-polyps ama-nasal kanye ne-sinusitis engapheli, inomthelela omkhulu weziguli empilweni. Ngakho-ke, ukuxilongwa okunembile kanye nokuphathwa kobufakazi okusekelwe ebufakazini kubalulekile.

Izici ezibalulekile ze-Eosinophilic asthma

1. Ukuvuvukala kwe-airway okuqhubekayo : Ukuqongelelwa ngokweqile kwe-eosinophil kuholela ekuvuvukeni kwezindiza okungamahlalakhona nokuvuvukala, ubunzima bokuphefumula.

2. Ukwanda okukhulu kwabadala : I-EA imvamisa iqala phakathi kweminyaka engama-25 no-35 futhi ilandela inkambo eyinkimbinkimbi yezifo kune-asthma ejwayelekile.

3. Ukusabela okulinganiselwe kokwelashwa okujwayelekile : Ukwelashwa kwe-corticosteroid yendabuko kungahle kube okusebenzayo, okuholela ekuphindekelweni kwezimpawu ezivame ukwenziwa noma kukhuleke.

4. Ubungozi obuphezulu be-comorbidity : I-EA imvamisa ehlotshaniswa nama-polyps nama-sinusitis angapheli, ukuqinisa izimpawu zokuphefumula kanye nokunciphisa okungeziwe kwempilo.

Ngabe kutholakala kanjani i-eosinophilic asthma?

Njengoba i-EA yabelana ngezimpawu nge-asthma ejwayelekile, ukubonakaliswa kwemitholampilo kuphela akwanele ukuxilongwa. Ukuhlolwa okulandelayo kwezokwelapha kusetshenziswa kakhulu:

• Ukuhlolwa kwegazi : Kala amazinga e-peripheral eosinophil amazinga wokuhlola ubungako bokuvuvukala.

• Ukuhlaziywa kwe-Sputum : Hlola isilinganiso se-eosinophil kumasampula we-sputum ukuqinisekisa uhlobo lokuvuvukala.

• Ukuhlolwa kokusebenza kwamaphaphu : ukuhlola ukuphazamiseka kwe-airway futhi kusize ekuhlukaniseni i-asthma.

• Ukuhlolwa kwe-Allergy : Hlukanisa i-EA kusuka ku-altthmarg asthma futhi wenze lula amasu okuthola ukwelashwa okwenziwe ngezifiso.

Izingozi ze-EA EZIQHAWULEKILE: ukukhathazeka okukhulu kwempilo

Uma kushiywe kungahlali, kungaholela ezinkingeni ezinzima, kufaka phakathi:

• I-Airway Remodeling : Ukuvuvukala okungamahlalakhona kungadala ushintsho oluhlelekile emigwaqweni yomoya, okuholela ekulimaleni kokuphefumula kwesikhathi eside.

• Ingozi eyandayo yokuhlaselwa kanzima : Iziguli ze-EA zithambekele kakhulu ekwakhiweni kwama-asthma okunzima, okuvame ukudinga ukulaliswa esibhedlela.

• Imithelela yezempilo ehleliwe : Izimo ze-comorbid, ezinjengezifo zokulala nokutheleleka kwamaphaphu, zingaqhubeka nempilo yonke kanye nenhlala-kahle.

Ukuphathwa kobufakazi okusekelwe e-EA: Ukwelashwa ngokunemba nokunakekelwa kwasekhaya

1. Izindlela zokwelapha zemvelo: Ukulawulwa kokuvuvukala okuhlosiwe

Intuthuko yakamuva kwezindlela zokwelapha ze-biologic zikhombisile imiphumela ethembisayo ekwelashweni kwe-EA. Lezi zindlela zokwelapha kufanele zilawulwe ngaphansi kokuqashwa kwezokwelapha:

• I-MepoLiZumab : Ivimbela ukukhiqizwa kwe-eosinophil, ukunciphisa ukuvuvukala emthonjeni wayo.

• I-Dupilumab : amabhlokhi wokuvuvukala ukuvuvukala kwezindlela, ukuvikela ngempumelelo i-asthma flare-ups.

2. Ukuqapha ekhaya kanye nokwelashwa okusekelayo: Ama-nebulizer we-joytech wokuphathwa okusebenzayo

Ngaphezu kokungenelela kwezokwelapha okungochwepheshe, amadivaysi okunakekelwa ekhaya adlala indima ebalulekile ekuphathweni kwezifo ze-Asthma. Ama-nebulizer we-JoyTech aklanyelwe ukwandisa ukulethwa kwemithi, ukuhlinzeka ngokusekelwa okusebenzayo kweziguli eziphethe i-EA ekhaya:

• Ukuncishiswa okusebenzayo okuphezulu : kukhiqiza izinhlayiya ezinhle ze-aerosol ukwenza ngcono ukumuncwa kwezidakamizwa futhi kunciphise isikhathi sokwelashwa.

• Ukusebenza okuthule : Idizayini yomsindo ophansi ivumela ukusetshenziswa ebusuku, okwenza kube kuhle ezinganeni naseziguli asebekhulile.

• Izinhlobo ze-inhalation ezimbaxambili : zifakwe imaski kanye nemilomo yemilomo yokuhlalisa izidingo ezahlukahlukene zesiguli, ithuthukise induduzo yokwelashwa.

Ukuphathwa okuphelele ngokuphathwa kwesayensi namadivayisi ahlakaniphile

Ukuphatha idinga inhlanganisela yokungenelela okuqondile kokwelashwa kanye nezixazululo ezisebenzayo zokunakekelwa kwasekhaya. Ngokwelashwa okuthuthukile kwe-biologic, ukubhekwa kwezifo eziqeqeshiwe, kanye namadivayisi wezokwelapha asezingeni eliphakeme anjenge-joytech nebulizers, iziguli zingasebenza nabahlinzeki bezokunakekelwa kwempilo ukuze bathole ukulawulwa kwabo okungcono kakhulu futhi kuthuthukise kakhulu ikhwalithi yabo yempilo.

Ama-nebulizer we-joyTech angamadivayisi wezokwelapha aklanyelwe ukusiza ekunakekelweni kokuphefumula. Sicela ulandele ukuholwa ngudokotela wakho ukuphathwa okufanele kwesifuba somoya.